Occult Primary

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Occult primary.

Overview Occult primary tumors, or cancers of unknown primary (CUPs), are defined as histologically proven metastatic malignant tumors whose primary site cannot be identified during pretreatment evaluation.1,2 They have a wide variety of clinical presentations and a poor prognosis in most patients. Patients with occult primary tumors often present with general complaints, such as anorexia and w...

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Occult primary, version 3.2014.

The NCCN Guidelines for Occult Primary tumors provide recommendations for the evaluation, workup, management, and follow-up of patients with occult primary tumors (cancers of unknown primary). These NCCN Guidelines Insights summarize major discussion points of the 2014 NCCN Occult Primary panel meeting. The panel discussed gene expression profiling (GEP) for the identification of the tissue of ...

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Occult primary head and neck carcinoma.

Unknown primary carcinoma presenting as cervical lymph node metastasis accounts for approximately 5% of all head and neck malignancies. The typical presentation involves a middle-aged man with a painless neck mass that has been present for several months. Over 90% of these malignancies represent squamous cell carcinoma originating within Waldeyer's ring (lymphoid tissue of the nasopharynx, tons...

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Occult Primary in the Head & Neck and its Diagnosis

Aim: To adopt a cost effective diagnostic protocol for occult primary. Methods: A prospective case control study of 50 patients presented with metastatic neck masses with unknown primary at Deptt. ENT Khyber Teaching Hospital, Peshawar, during April 2008 to Dec. 2009. Results: Male; female ratio was 18 versus 32, 1.78; 1. Male with advanced age (45-65 year) had major share 28(56%). Malignancy w...

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The mammaglobin gene encodes a novel, breast cancer-associated glycoprotein. In this study, we have evaluated the frequency with which mammaglobin expression can be detected in primary and metastatic breast tumors and in breast tumor cells present in the peripheral circulation. Of 100 primary human breast tumors examined, 81 were strongly immunopositive for mammaglobin protein. Staining was ind...

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ژورنال

عنوان ژورنال: Journal of the National Comprehensive Cancer Network

سال: 2011

ISSN: 1540-1405,1540-1413

DOI: 10.6004/jnccn.2011.0117